HI-TRON Mainz
« It's a perfect playground for scientists »
– M.V.
POSITION
Postdoctoral Scientist - High-throughput Immunopeptidomics Platform (ID: 2023-0433)
POSITION
Postdoctoral Scientist
DEPARTMENT
High-throughput Immunopeptidomics Platform
Code number
2023-0433
Earliest Possible Start Date
As soon as possible
Duration
2 years with possibility of prolongation
Application Deadline
*The position can in principle be part-time.
The German Cancer Research Center is the largest biomedical research institution in Germany. With more than 3,000 employees, we operate an extensive scientific program in the field of cancer research.
The Helmholtz Institute HI-TRON is a collaboration of the German Cancer Research Center (DKFZ) with the Research Institute for Translational Oncology at the University Medical Center of the Johannes Gutenberg University Mainz (TRON gGmbH), the University Medical Center Mainz and the Johannes Gutenberg University Mainz. The goal of the partnership is to develop effective immunotherapies and to identify novel biomarkers for assessing the effectiveness of treatment.
The "High-throughput Immunopeptidomics Platform" aims to identify cancer-specific immunopeptides (MHC-ligands), antigens that can trigger the immune response, and potential targets for immunotherapy. To achieve this, we develop and implement LC-MS-based workflows to scrutinize the immunopeptidome in clinical, preclinical, and in vitro studies. Headed by Dr. David Gomez-Zepeda, the platform was founded in June 2023 to provide scientists with cutting-edge LC-MS immunopeptidomics infrastructure and expertise. We are associated with the lab of Prof. Dr. Stefan Tenzer, forming a team of international and multi-disciplinary scientists in an innovation-driven environment.
Job description
The project objective is to develop high-throughput workflows for sample preparation, LC-MS acquisition, and/or data analysis of immunopeptidomics experiments. To facilitate clinical studies, the goal is to achieve the analysis of hundreds of samples per week. The scientist will contribute to collaboration projects from the study design to data analysis and interpretation, aiming to identify antigens in diverse types of cancer in cell culture, tumor, and plasma samples. The specific goals will be adapted to the profile and interests of the selected applicant.
Main tasks:
- Planning and performing experiments and analyzing, interpreting, and reporting the results
- Communicating with collaboration partners and assisting in the coordination of students and technical staff
- Writing scientific publications and presenting at national and/or international conferences
- Optional: operating and maintaining LC-MS instruments (Evosep-One coupled to timsTOF Ultra), and/or the sample preparation robot (Opentrons)
Requirements
- Ph.D. with experience in biochemistry, biotechnology, analytical chemistry, bioinformatics, computational biology, or related fields; or M.Sc. with more than two years of experience
- Keen interest in bioanalytical chemistry, mass spectrometry, biochemistry, immunology, and/or oncology
- Previous experience with MS-based omics and related data analysis is an advantage, but not required
- Strong communication skills in English are required, knowledge of German is advantageous, but not required
- Creativity and strong analytical thinking
- Enthusiastic and motivated team player
We offer
Excellent framework conditions: state-of-the-art equipment and opportunities for international networking at the highest level
Remuneration according to TV-L incl. occupational pension plan and capital-forming payments
30 days of vacation per year
Flexible working hours
Possibility of mobile work and part-time work
Family-friendly working environment, e.g. parent-child room, advisory services caring for elderly relatives
Sustainable travel to work: subsidized Germany job ticket
Unleash your full potential: targeted offers for your personal development to further develop your talents
Our Corporate Health Management Program offers a holistic approach to your well-being
Important notice
The DKFZ is subject to the regulations of the Infection Protection Act (IfSG). As a consequence, only persons who present proof of immunity against measles may work at the DKFZ.
Contact
Dr. Julia Neuhaus
Phone +49 6131 2161 141
Please note that we do not accept applications submitted via email.
The DKFZ is committed to increase the proportion of women in all areas and positions in which women are underrepresented. Qualified female applicants are therefore particularly encouraged to apply.
Among candidates of equal aptitude and qualifications, a person with disabilities will be given preference.
To apply for a position please use our online application portal or via the button below.
We ask for your understanding that we cannot return application documents that are sent to us by post (Deutsches Krebsforschungszentrum, Personalabteilung, Im Neuenheimer Feld 280, 69120 Heidelberg) and that we do not accept applications submitted via email. We apologize for any inconvenience this may cause.
