Translational Immunotherapy Group

Prof. Dr. Niels Halama

Integrating broad aspects of immunological parameters

for the successful development and optimization

of therapeutic approaches in clinical translation

OUR RESEARCH

Why it matters

Cancer immunotherapy has revolutionized oncology. As a standard of care for some cancer entities, broad application in the treatment of patients with hematologic and solid tumors has become a reality. Identification of patients for a specific immunomodulatory approach, identification of successful combinatorial immunotherapy (or combination with chemotherapy, radiation or other intervention) are all important next steps to be developed. Utilizing new model systems and informative trial designs, the connection of basic research and translational efforts make this area highly diverse and challenging, but show the potential for a future of personalized therapy in oncology.

HALAMA LAB

Lab focus

Cancer immunology has moved from scientific insight into practice changing standards in oncology. Robust scientific evidence has provided the entry to successful clinical translation.

The division of translational immunotherapy is integrating broad aspects of immunological parameters (i.e. tissue-specific regulation, microbiome, metabolic regulation, genomic factors etc.) for the successful development and optimization of therapeutic approaches in clinical translation.

An important part is to better understand the regulation of immune responses within tissues of solid tumors. Dedicated biomarker research for the identification of relevant immune cell phenotypes is also a decisive factor like understanding the cytokine regulatory network in specific disease situations. Deeper insights into the situation in human patients are provided by our fully-human preclinical Explant Model System, which is able to recapitulate the microenvironment of individual patients.
In addition, new computational model systems, databases and machine learning (“artificial intelligence”) allow to further elaborate our understanding of the regulation of immune responses. Especially our explant model systems open new possibilities in development of new therapies. Newly developed therapies have been successfully translated into the clinic and combinatorial immunomodulation based on adaptive clinical trial protocols with biomarker driven selection programs are now being implemented.

Group Leader Translational Immunotherapy

Prof. Dr. Niels Halama

Contact

[since 2023] Head of Division, HI-TRON Mainz
[2019- 2023] Head of the Department of Translational Immunotherapy, DKFZ
[2015 – 2019] Group leader, University of Heidelberg, NCT
[2008- 2023] Scientist at NCT; TIGA; DKFZ
[2005 – 2006] Resident and Fellow, NCT
[1999 - 2005] Student at University of Heidelberg

[2012] Best Poster Award AACR (unter mehr als 10.000 Postern von den Gutachtern bestens bewertet)
[2012] Forschungspreis der Dr. Feldbausch Stiftung
[2009] Scientific Excellence Certificate & Best Poster Award, International Cancer Microenvironment Society (ICMS)
[2007] Young Investigator Award, Medizinische Fakultät der Universität Heidelberg
[1998] Stipendium der "Studienstiftung des deutschen Volkes"

[2012 - present] Deutsche Gesellschaft für Immunologie (DGfI)
[2009-present] American Association for Cancer Research (AACR), USA (AACR-sponsored membership), member of the Cancer Immunology Working Group (CIMM)
[2011 - heute] International Society for Translational Medicine
[2009 - 2012] National Society for Histotechnology (NSH), USA
[2007 - heut] International Cancer Microenvironment Society (ICMS)
[2003 - 2006] Editor and Author, Section "Endocrinology” and “Neurology", for Medicle (www.medicle.org)

HI-TRON Mainz DKFZ
AG Halama
Obere Zahlbacherstr. 63
Building 911
55131 Mainz

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